Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 4
Synthesis and antibacterial activity of hnew hydrazide-hydrazones derived from Benzocaine
Muhammed İhsan HAN1,Güler GÜROL1,Temel YILDIRIM1,Sadık KALAYCI2,Fikrettin ŞAHİN2,Ş. Güniz KÜÇÜKGÜZEL1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Haydarpaşa 34668 İstanbul, Turkey
2Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, Kayışdağı, İstanbul, Turkey
DOI : 10.12991/mpj.2017.34 A novel series of new eleven benzocaine hydrazide derivatives, N-(4-{[2-(nonsubstituted/ substitutedfuryl/ phenyl/ pyridinyl/ thienyl/ pyrrole)methylidene]hydrazinyl] carbonyl}phenyl) benzamides [3a-k] have been synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR and 1H-NMR) methods and their purity was proven by elemental analysis and thin layer chromatography. These compounds were evaluated for in vitro antibacterial activity by using micro-well dilution method against Escherichia coli ATCC 10536, Escherichia coli ATCC 15442, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15442, Acinetobacter baumannii , Klebsiella pneumonia ATCC 13883. Keywords : Antibacterial activity; Benzocaine; hydrazidehydrazone; azomethine