Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 4
Chemical composition, antioxidant, anticholinesterase and anti-urease activities of Sideritis pisidica Boiss. & Heldr. endemic to Turkey
Ebru Deveci1,Gülsen Tel-Çayan2,Hasan Yıldırım3,Mehmet Emin Duru1
1Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Muğla, Turkey
2Department of Chemistry and Chemical Processing Technologies, Muğla Vocational School, Muğla Sıtkı Koçman University, Muğla, Turkey
3Department of Biology, Faculty of Science, Ege University, İzmir, Turkey
DOI : 10.12991/mpj.2017.13 The objective of this study was to investigate the chemical composition, antioxidant, anticholinesterase and anti-urease activities of essential oil, hexane, acetone and methanol extracts of Sideritis pisidica Boiss. & Heldr. The essential oil and fatty acid composition were analyzed by GC and GC/MS. δ-Cadinene (19.5 %), T-cadinol (16.7 %) and β-cubebene (10.4 %) were identified as the main compounds of the essential oil whereas the most abundant compounds of fatty acids were found as linolenic (42.7 %), palmitic (31.3 %) and linoleic (13.4%) acids. The methanol extract demonstrated the highest antioxidant activity in all tests, except for metal chelating assay. The hexane extract was found to be significantly active in metal chelating (IC50: 22.97±1.36 μg/mL), acetylcholinesterase (62.54±0.88 %) and urease inhibitory (78.93±0.17 %) assays. These results show that the Sideritis pisidica could be used as the potential source of natural products in the food and pharmaceutical areas. Keywords : Sideritis pisidica; essential oil; fatty acid; antioxidant activity; anticholinesterase activity; anti-urease activity